The researchers also discovered that AS therapy was connected with a significantly even worse objective response rate , and also lower prices of erlotinib treatment-limiting toxicity and TKI-related rash . Sawyer et al comment that they could not determine whether there is a threshold for the amount of concomitant AS therapy that may influence erlotinib because the bulk of AS-therapy sufferers received 100 percent prescription overlap with erlotinib. Research are warranted to determine if this impact applies to other TKIs. All rights reserved. Neither of these ongoing parties endorse or recommend any commercial products, services, or equipment.. Antacids linked to reduced erlotinib efficacy By Laura Cowen, medwireNews Reporter Acid suppression therapy might negatively impact outcome among individuals receiving erlotinib for advanced non-small-cell lung malignancy , Canadian study findings show.‘ABT-737 targets proteins from the Bcl-2 family, which are located at high levels in up to 70 percent of breast cancers,’ Dr Lindeman said. ‘We’ve shown that breast tumours which have high levels of Bcl-2 react well to treatment with ABT-737 when found in combination with a typical chemotherapy drug.’ ABT-737 and navitoclax were uncovered by Abbott scientists and are predicated on the discovery produced at the Walter and Eliza Hall Institute in the 1980s that Bcl-2 is normally a ‘pro-survival’ protein responsible for preventing cell death in healthy and diseased cells. Navitoclax and ABT-737 aren’t yet designed for patient treatment, but navitoclax happens to be in phase II scientific trials to determine its efficacy in treating some types of leukaemia and lymphoma.